TY  - JOUR
A1  - Kleinert, Robin D. V.
A1  - Montoya-Diaz, Eduardo
A1  - Khera, Tanvi
A1  - Welsch, Kathrin
A1  - Tegtmeyer, Birthe
A1  - Hoehl, Sebastian
A1  - Ciesek, Sandra
A1  - Brown, Richard J. P.
T1  - Yellow fever: Integrating current knowledge with technological innovations to identify strategies for controlling a re-emerging virus
T2  - Viruses
N2  - Yellow fever virus (YFV) represents a re-emerging zoonotic pathogen, transmitted by mosquito vectors to humans from primate reservoirs. Sporadic outbreaks of YFV occur in endemic tropical regions, causing a viral hemorrhagic fever (VHF) associated with high mortality rates. Despite a highly effective vaccine, no antiviral treatments currently exist. Therefore, YFV represents a neglected tropical disease and is chronically understudied, with many aspects of YFV biology incompletely defined including host range, host–virus interactions and correlates of host immunity and pathogenicity. In this article, we review the current state of YFV research, focusing on the viral lifecycle, host responses to infection, species tropism and the success and associated limitations of the YFV-17D vaccine. In addition, we highlight the current lack of available treatments and use publicly available sequence and structural data to assess global patterns of YFV sequence diversity and identify potential drug targets. Finally, we discuss how technological advances, including real-time epidemiological monitoring of outbreaks using next-generation sequencing and CRISPR/Cas9 modification of vector species, could be utilized in future battles against this re-emerging pathogen which continues to cause devastating disease.
KW  - yellow fever virus
KW  - flavivirus entry factor
KW  - global diversity
KW  - yellow fever virus tropism
KW  - animal models
KW  - transmission and vector control
KW  - vaccine
KW  - host immune response
KW  - E protein structure
KW  - re-emerging virus
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/52570
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-525700
SN  - 1999-4915
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 10
IS  - 10, Art. 960
SP  - 1
EP  - 32
PB  - MDPI
CY  - Basel
ER  -