TY  - JOUR
A1  - Sullivan, Mairéad
A1  - Fernández-Aranda, Fernando
A1  - Camacho-Barcia, Lucía
A1  - Harkin, Andrew
A1  - Macrì, Simone
A1  - Mora-Maltas, Bernat
A1  - Jiménez-Murcia, Susana
A1  - O'Leary, Aet
A1  - Ottomana, Angela Maria
A1  - Presta, Martina
A1  - Slattery, David A.
A1  - Scholtz, Samantha
A1  - Glennon, Jeffrey C.
T1  - Insulin and disorders of behavioural flexibility
T2  - Neuroscience & biobehavioral reviews
N2  - Behavioural inflexibility is a symptom of neuropsychiatric and neurodegenerative disorders such as Obsessive-Compulsive Disorder, Autism Spectrum Disorder and Alzheimer’s Disease, encompassing the maintenance of a behaviour even when no longer appropriate. Recent evidence suggests that insulin signalling has roles apart from its regulation of peripheral metabolism and mediates behaviourally-relevant central nervous system (CNS) functions including behavioural flexibility. Indeed, insulin resistance is reported to generate anxious, perseverative phenotypes in animal models, with the Type 2 diabetes medication metformin proving to be beneficial for disorders including Alzheimer’s Disease. Structural and functional neuroimaging studies of Type 2 diabetes patients have highlighted aberrant connectivity in regions governing salience detection, attention, inhibition and memory. As currently available therapeutic strategies feature high rates of resistance, there is an urgent need to better understand the complex aetiology of behaviour and develop improved therapeutics. In this review, we explore the circuitry underlying behavioural flexibility, changes in Type 2 diabetes, the role of insulin in CNS outcomes and mechanisms of insulin involvement across disorders of behavioural inflexibility.
KW  - Insulin
KW  - IGF1
KW  - Neuropsychiatric disorders
KW  - Type 2 diabetes
KW  - Metformin
KW  - Obsessive-compulsive disorder
KW  - Autism spectrum disorder
KW  - Addiction
KW  - Anorexia Nervosa
KW  - Obesity
KW  - Alzheimer’s disease
KW  - Parkinson’s disease
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78958
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-789582
SN  - 0149-7634
VL  - 150
IS  - 105169
PB  - Elsevier
CY  - Amsterdam
ER  -