TY  - JOUR
A1  - Grünewald, Leon David
A1  - Koch, Vitali
A1  - Martin, Simon
A1  - Yel, Ibrahim
A1  - Eichler, Katrin
A1  - Gruber-Rouh, Tatjana
A1  - Lenga, Lukas Fabian
A1  - Wichmann, Julian
A1  - Alizadeh, Leona Soraja
A1  - Albrecht, Moritz Hans Ernst
A1  - Mader, Christoph
A1  - Huizinga, Nicole A.
A1  - D’Angelo, Tommaso
A1  - Mazziotti, Silvio
A1  - Wesarg, Stefan
A1  - Vogl, Thomas J.
A1  - Booz, Christian
T1  - Diagnostic accuracy of quantitative dual-energy CT-based volumetric bone mineral density assessment for the prediction of osteoporosis-associated fractures
T2  - European radiology
N2  - Objectives: To evaluate the predictive value of volumetric bone mineral density (BMD) assessment of the lumbar spine derived from phantomless dual-energy CT (DECT)-based volumetric material decomposition as an indicator for the 2-year occurrence risk of osteoporosis-associated fractures. Methods: L1 of 92 patients (46 men, 46 women; mean age, 64 years, range, 19–103 years) who had undergone third-generation dual-source DECT between 01/2016 and 12/2018 was retrospectively analyzed. For phantomless BMD assessment, dedicated DECT postprocessing software using material decomposition was applied. Digital files of all patients were sighted for 2 years following DECT to obtain the incidence of osteoporotic fractures. Receiver operating characteristic (ROC) analysis was used to calculate cut-off values and logistic regression models were used to determine associations of BMD, sex, and age with the occurrence of osteoporotic fractures. Results: A DECT-derived BMD cut-off of 93.70 mg/cm3 yielded 85.45% sensitivity and 89.19% specificity for the prediction to sustain one or more osteoporosis-associated fractures within 2 years after BMD measurement. DECT-derived BMD was significantly associated with the occurrence of new fractures (odds ratio of 0.8710, 95% CI, 0.091–0.9375, p < .001), indicating a protective effect of increased DECT-derived BMD values. Overall AUC was 0.9373 (CI, 0.867–0.977, p < .001) for the differentiation of patients who sustained osteoporosis-associated fractures within 2 years of BMD assessment. Conclusions: Retrospective DECT-based volumetric BMD assessment can accurately predict the 2-year risk to sustain an osteoporosis-associated fracture in at-risk patients without requiring a calibration phantom. Lower DECT-based BMD values are strongly associated with an increased risk to sustain fragility fractures.
Key Points: Dual-energy CT–derived assessment of bone mineral density can identify patients at risk to sustain osteoporosis-associated fractures with a sensitivity of 85.45% and a specificity of 89.19%. The DECT-derived BMD threshold for identification of at-risk patients lies above the American College of Radiology (ACR) QCT guidelines for the identification of osteoporosis (93.70 mg/cm 3 vs 80 mg/cm 3 ).
KW  - Bone density
KW  - Osteoporosis
KW  - Osteoporotic fractures
KW  - Bone diseases, Metabolic
KW  - CT dual-energy computed tomography
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64055
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-640558
SN  - 1432-1084
VL  - 2021
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -