TY  - JOUR
A1  - Bernatz, Simon
A1  - Monden, Daniel
A1  - Geßler, Florian
A1  - Radić, Tijana
A1  - Hattingen, Elke
A1  - Senft, Christian
A1  - Seifert, Volker
A1  - Ronellenfitsch, Michael Wilfried
A1  - Plate, Karl
A1  - Harter, Patrick Nikolaus
A1  - Baumgarten, Peter
T1  - Influence of VEGF-A, VEGFR-1-3, and neuropilin 1-2 on progression-free: and overall survival in WHO grade II and III meningioma patients
T2  - Journal of molecular histology
N2  - Higher grade meningiomas tend to recur. We aimed to evaluate protein levels of vascular endothelial growth factor (VEGF)-A with the VEGF-receptors 1-3 and the co-receptors Neuropilin (NRP)-1 and -2 in WHO grade II and III meningiomas to elucidate the rationale for targeted treatments. We investigated 232 specimens of 147 patients suffering from cranial meningioma, including recurrent tumors. Immunohistochemistry for VEGF-A, VEGFR-1-3, and NRP-1/-2 was performed on tissue micro arrays. We applied a semiquantitative score (staining intensity x frequency). VEGF-A, VEGFR-1-3, and NRP-1 were heterogeneously expressed. NRP-2 was mainly absent. We demonstrated a significant increase of VEGF-A levels on tumor cells in WHO grade III meningiomas (p = 0.0098). We found a positive correlation between expression levels of VEGF-A and VEGFR-1 on tumor cells and vessels (p < 0.0001). In addition, there was a positive correlation of VEGF-A and VEGFR-3 expression on tumor vessels (p = 0.0034). VEGFR-2 expression was positively associated with progression-free survival (p = 0.0340). VEGF-A on tumor cells was negatively correlated with overall survival (p = 0.0084). The VEGF-A-driven system of tumor angiogenesis might still present a suitable target for adjuvant therapy in malignant meningioma disease. However, its role in malignant tumor progression may not be as crucial as expected. The value of comprehensive testing of the ligand and all receptors prior to administration of anti-angiogenic therapy needs to be evaluated in clinical trials.
KW  - Meningioma
KW  - VEGF
KW  - VEGF receptors
KW  - Neuropilin
KW  - Malignant meningioma
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/74729
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-747298
SN  - 1567-2387
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 52
IS  - 2
SP  - 233
EP  - 243
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht [u.a.]
ER  -