TY  - INPR
A1  - Mühlroth, Beate Elisabeth
A1  - Sander, Myriam Christine
A1  - Fandakova, Yana
A1  - Grandy, Thomas H.
A1  - Rasch, Björn
A1  - Shing, Yee Lee
A1  - Werkle-Bergner, Markus
T1  - Precise slow oscillation-spindle coupling promotes memory consolidation in younger and older adults
T2  - bioRxiv
N2  - Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO) and sleep spindles (SP) and their coupling across the adult human lifespan and ask whether observed alterations relate to the ability to retain associative memories across sleep. We demonstrate that the fine-tuned SO–SP coupling that is present in younger adults diffuses with advanced age and shifts both in time and frequency. Crucially, we show that the tight precision of SO–SP coupling promotes memory consolidation in younger and older adults, and that brain integrity in source regions for the generation of SOs and SPs reinforces this beneficial SO–SP coupling in old age. Our results reveal age-related differences in SO–SP coupling in healthy elderly individuals. Furthermore, they broaden our understanding of the conditions and the functional significance of SO–SP coupling across the entire adult lifespan.
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72488
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-724887
IS  - 268474
ER  -