TY  - JOUR
A1  - Fischer-Rasokat, Ulrich
A1  - Renker, Matthias
A1  - Liebetrau, Christoph
A1  - Weferling, Maren
A1  - Rolf, Andreas
A1  - Doss, Mirko
A1  - Möllmann, Helge
A1  - Walther, Thomas
A1  - Hamm, Christian
A1  - Kim, Won-Keun
T1  - Outcome of patients with heart failure after transcatheter aortic valve implantation
T2  - PLoS one
N2  - Aims: Patients with aortic stenosis (AS) may have concomitant heart failure (HF) that determines prognosis despite successful transcatheter aortic valve implantation (TAVI). We compared outcomes of TAVI patients with low stroke volume index (SVI) ≤35 ml/m2 body surface area in different HF classes.
Methods and results: Patients treated by transfemoral TAVI at our center (n = 1822) were classified as 1) ‘HF with preserved ejection fraction (EF)’ (HFpEF, EF ≥50%), 2) ‘HF with mid-range EF’ (HFmrEF, EF 40–49%), or 3) ‘HF with reduced EF’ (HFrEF, EF <40%). Patients with SVI >35 ml/m2 served as controls. The prevalence of cardiovascular disease and symptoms increased stepwise from controls (n = 968) to patients with HFpEF (n = 591), HFmrEF (n = 97), and HFrEF (n = 166). Mortality tended to be highest in HFrEF patients 30 days post-procedure, and it became significant after one year: 10.2% (controls), 13.5% (HFpEF), 13.4% (HFmrEF), and 23.5% (HFrEF). However, symptomatic improvement in survivors of all groups was achieved in the majority of patients without differences among groups.
Conclusions: Patients with AS and HF benefit from TAVI with respect to symptom alleviation. TAVI in patients with HFpEF and HFmrEF led to an identical, favorable post-procedural prognosis that was significantly better than that of patients with HFrEF, which remains a high-risk population.
KW  - Heart failure
KW  - Death rates
KW  - Ejection fraction
KW  - Aortic valve
KW  - Chronic obstructive pulmonary disease
KW  - Prognosis
KW  - Blood pressure
KW  - Body mass index
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51705
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-517053
SN  - 1932-6203
N1  - Copyright: © 2019 Fischer-Rasokat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 14
IS  - (11): e0225473
SP  - 1
EP  - 13
PB  - PLoS
CY  - Lawrence, Kan.
ER  -