TY  - JOUR
A1  - Grimm, Oliver
A1  - Rooij, Daan van
A1  - Tshagharyan, Asya
A1  - Yildiz, Dilek
A1  - Leonards, Jan
A1  - Elgohary, Ahmed
A1  - Buitelaar, Jan K.
A1  - Reif, Andreas
T1  - Effects of comorbid disorders on reward processing and connectivity in adults with ADHD
T2  - Translational Psychiatry
N2  - ADHD is a neurodevelopmental disorder with a long trajectory into adulthood where it is often comorbid with depression, substance use disorder (SUD) or obesity. Previous studies described a dysregulated dopaminergic system, reflected by abnormal reward processing, both in ADHD as well as in depression, SUD or obesity. No study so far however tested systematically whether pathologies in the brain’s reward system explain the frequent comorbidity in adult ADHD. To test this, we acquired MRI scans from 137 participants probing the reward system by a monetary incentive delay task (MIDT) as well as assessing resting-state connectivity with ventral striatum as a seed mask. No differences were found between comorbid disorders, but a significant linear effect pointed toward less left intrastriatal connectivity in patients depending on the number of comorbidities. This points towards a neurobiologically impaired reward- and decision-making ability in patients with more comorbid disorders. This suggests that less intrastriatal connectivity parallels disorder severity but not disorder specificity, while MIDT abnormalities seem mainly to be driven by ADHD.
KW  - ADHD
KW  - Diagnostic markers
KW  - Human behaviour
KW  - Neuroscience
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69543
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-695431
SN  - 2158-3188
N1  - Financial support for this study was received from the European Union’s Horizon 2020 research and innovation program under grant agreement 667302: Comorbid Conditions of ADHD (CoCA).
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 11
IS  - art. 636
SP  - 1
EP  - 7
PB  - Nature Publishing Group
CY  - London
ER  -