TY  - JOUR
A1  - Müller, Diana
A1  - Saha, Puja
A1  - Panda, Deepanjan
A1  - Dash, Jyotirmayee
A1  - Schwalbe, Harald
T1  - Insights from binding on quadruplex selective carbazole ligands
T2  - Chemistry - a European journal
N2  - Polymorphic G-quadruplex (G4) secondary DNA structures have received increasing attention in medicinal chemistry owing to their key involvement in the regulation of the maintenance of genomic stability, telomere length homeostasis and transcription of important proto-oncogenes. Different classes of G4 ligands have been developed for the potential treatment of several human diseases. Among them, the carbazole scaffold with appropriate side chain appendages has attracted much interest for designing G4 ligands. Because of its large and rigid π-conjugation system and ease of functionalization at three different positions, a variety of carbazole derivatives have been synthesized from various natural or synthetic sources for potential applications in G4-based therapeutics and biosensors. Herein, we provide an updated close-up of the literatures on carbazole-based G4 ligands with particular focus given on their detailed binding insights studied by NMR spectroscopy. The structure-activity relationships and the opportunities and challenges of their potential applications as biosensors and therapeutics are also discussed. This review will provide an overall picture of carbazole ligands with remarkable G4 topological preference, fluorescence properties and significant bioactivity; portraying carbazole as a very promising scaffold for assembling G4 ligands with a range of novel functional applications.
KW  - biophysics
KW  - carbazole ligands
KW  - G-quadruplexes
KW  - ligand design
KW  - NMR spectroscopy
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63919
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-639194
SN  - 1521-3765
N1  - D.M. and H.S. were supported by DFG CRC902 and by iNEXT, project number 653706, funded by the Horizon 2020 program of the European Union. Work at BMRZ is supported by the state of Hesse. JD thanks Wellcome Trust-DBT India Alliance [Grant Number, IA/S/18/2/503986] and CSIR-INDIA for research funding. Open access funding enabled and organized by Projekt DEAL.
VL  - 27
IS  - 50
SP  - 12726
EP  - 12736
PB  - Wiley-VCH
CY  - Weinheim
ER  -