TY  - JOUR
A1  - Sayin, Sercan
A1  - De Backer, Jean-Francois
A1  - Siju, Kunhi Purayil
A1  - Wosniack, Marina Elaine
A1  - Lewis, Laurence P.
A1  - Frisch, Lisa-Marie
A1  - Gansen, Benedikt
A1  - Schlegel, Philipp
A1  - Edmondson-Stait, Amelia
A1  - Sharifi, Nadiya
A1  - Fisher, Corey B.
A1  - Calle-Schuler, Steven A.
A1  - Lauritzen, J. Scott
A1  - Bock, Davi D.
A1  - Costa, Marta
A1  - Jefferis, Gregory S. X. E.
A1  - Gjorgjieva, Julijana
A1  - Grunwald Kadow, Ilona
T1  - A neural circuit arbitrates between persistence and withdrawal in Hungry drosophila
T2  - Neuron
N2  - In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.
KW  - DopR2
KW  - Drosophila melanogaster
KW  - dopamine
KW  - foraging
KW  - goal-directed behavior
KW  - learning
KW  - mushroom body
KW  - octopamine
KW  - olfactory system
KW  - persistence
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54548
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-545482
SN  - 1097-4199
SN  - 0896-6273
N1  - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
VL  - 104
IS  - 3
SP  - 544
EP  - 558.e6
PB  - Cell Press ; Elsevier
CY  - [Cambridge, Mass.] ; New York, NY
ER  -