TY  - JOUR
A1  - Giroud, Jérémy
A1  - Trébuchon, Agnès
A1  - Schön, Daniele
A1  - Marquis, Patrick
A1  - Liegeois-Chauvel, Catherine
A1  - Poeppel, David
A1  - Morillon, Benjamin
T1  - Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy
T2  - PLoS biology
N2  - Speech perception is mediated by both left and right auditory cortices but with differential sensitivity to specific acoustic information contained in the speech signal. A detailed description of this functional asymmetry is missing, and the underlying models are widely debated. We analyzed cortical responses from 96 epilepsy patients with electrode implantation in left or right primary, secondary, and/or association auditory cortex (AAC). We presented short acoustic transients to noninvasively estimate the dynamical properties of multiple functional regions along the auditory cortical hierarchy. We show remarkably similar bimodal spectral response profiles in left and right primary and secondary regions, with evoked activity composed of dynamics in the theta (around 4–8 Hz) and beta–gamma (around 15–40 Hz) ranges. Beyond these first cortical levels of auditory processing, a hemispheric asymmetry emerged, with delta and beta band (3/15 Hz) responsivity prevailing in the right hemisphere and theta and gamma band (6/40 Hz) activity prevailing in the left. This asymmetry is also present during syllables presentation, but the evoked responses in AAC are more heterogeneous, with the co-occurrence of alpha (around 10 Hz) and gamma (>25 Hz) activity bilaterally. These intracranial data provide a more fine-grained and nuanced characterization of cortical auditory processing in the 2 hemispheres, shedding light on the neural dynamics that potentially shape auditory and speech processing at different levels of the cortical hierarchy.
KW  - Auditory cortex
KW  - Left hemisphere
KW  - Syllables
KW  - Language
KW  - Acoustics
KW  - Right hemisphere
KW  - Medical implants
KW  - Speech
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/53063
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-530634
SN  - 1545-7885
SN  - 1544-9173
N1  - Copyright: © 2020 Giroud et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 18
IS  - (3): e3000207
SP  - 1
EP  - 20
PB  - PLoS
CY  - Lawrence, KS
ER  -