TY  - JOUR
A1  - Hensch, Tilman
A1  - Wozniak, David
A1  - Spada, Janek
A1  - Sander, Christian
A1  - Ulke, Christine
A1  - Wittekind, Dirk Alexander
A1  - Thiery, Joachim
A1  - Löffler, Markus
A1  - Jawinski, Philippe
A1  - Hegerl, Ulrich
T1  - Vulnerability to bipolar disorder is linked to sleep and sleepiness
T2  - Translational Psychiatry
N2  - Sleep impairments are a hallmark of acute bipolar disorder (BD) episodes and are present even in the euthymic state. Studying healthy subjects who are vulnerable to BD can improve our understanding of whether sleep impairment is a predisposing factor. Therefore, we investigated whether vulnerability to BD, dimensionally assessed by the hypomanic personality scale (HPS), is associated with sleep disturbances in healthy subjects. We analyzed participants from a population-based cohort who had completed the HPS and had either a 7-day actigraphy recording or a Pittsburgh sleep quality index (PSQI) assessment. In addition, subjects had to be free of confounding diseases or medications. This resulted in 771 subjects for actigraphy and 1766 for PSQI analyses. We found strong evidence that higher HPS scores are associated with greater intraindividual sleep variability, more disturbed sleep and more daytime sleepiness. In addition, factor analyses revealed that core hypomanic features were especially associated with self-reported sleep impairments. Results support the assumption of disturbed sleep as a possibly predisposing factor for BD and suggest sleep improvement as a potential early prevention target.
KW  - Bipolar disorder
KW  - Human behaviour
KW  - Pathogenesis
KW  - Predictive markers
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/53327
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-533279
SN  - 2158-3188
N1  - Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
VL  - 9
IS  - 1, Art. 294
SP  - 1
EP  - 10
PB  - Nature Publishing Group
CY  - London
ER  -