TY  - JOUR
A1  - Hedskog, Charlotte
A1  - Parhy, Bandita
A1  - Chang, Silvia
A1  - Zeuzem, Stefan
A1  - Moreno, Christophe
A1  - Shafran, Stephen D.
A1  - Borgia, Sergio M.
A1  - Asselah, Tarik
A1  - Alric, Laurent
A1  - Abergel, Armand
A1  - Chen, Jyh-Jou
A1  - Collier, Jane
A1  - Kapoor, Dharmesh
A1  - Hyland, Robert
A1  - Simmonds, Peter
A1  - Mo, Hongmei
A1  - Svarovskaia, Evguenia S.
T1  - Identification of 19 novel hepatitis C virus subtypes—further expanding HCV classification
T2  - Open Forum Infectious Diseases
N2  - Background: Hepatitis C virus (HCV) is currently classified into 8 genotypes and 86 subtypes. The objective of this study was to characterize novel HCV subtypes and to investigate the impact of subtypes on treatment outcome.
Methods: Full-genome sequencing was performed on HCV plasma samples with <85% sequence homology of NS3, NS5A, and/or NS5B to HCV genotype (GT) 1–8 reference strains.
Results: A total of 14 653 patients with GT1–6 HCV infection were enrolled in clinical studies of sofosbuvir-based regimens. For the majority of the patients, a specific subtype could be assigned based on a close genetic relationship to previously described subtypes. However, for 19 patients, novel subtypes were identified with <85% homology compared with previously described subtypes. These novel subtypes had the following genotypes: 9 in GT2, 5 in GT4, 2 in GT6, and 1 each in GT1, GT3, and GT5. Despite the presence of polymorphisms at resistance-associated substitution positions, 18 of the 19 patients treated with sofosbuvir-containing therapy achieved SVR12.
Conclusions: Nineteen novel HCV subtypes were identified, suggesting an even greater genetic diversity of HCV subtypes than previously recognized.
KW  - direct-acting antivirals (DAAs)
KW  - phylogenetic analysis
KW  - resistance-associated substitutions (RAS)
KW  - sofosbuvir
KW  - velpatasvir
KW  - voxilaprevir
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50159
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-501593
SN  - 2328-8957
N1  - This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
VL  - 6
IS  - 3, ofz076
SP  - 1
EP  - 9
PB  - Oxford University Press
CY  - Oxford
ER  -