TY  - JOUR
A1  - Reichlmeir, Marina
A1  - Elias, Lena
A1  - Schulte, Dorothea
T1  - Posttranslational modifications in conserved transcription factors: a survey of the TALE-homeodomain superclass in human and mouse
T2  - Frontiers in cell and developmental biology
N2  - Transcription factors (TFs) guide effector proteins like chromatin-modifying or -remodeling enzymes to distinct sites in the genome and thereby fulfill important early steps in translating the genome’s sequence information into the production of proteins or functional RNAs. TFs of the same family are often highly conserved in evolution, raising the question of how proteins with seemingly similar structure and DNA-binding properties can exert physiologically distinct functions or respond to context-specific extracellular cues. A good example is the TALE superclass of homeodomain-containing proteins. All TALE-homeodomain proteins share a characteristic, 63-amino acid long homeodomain and bind to similar sequence motifs. Yet, they frequently fulfill non-redundant functions even in domains of co-expression and are subject to regulation by different signaling pathways. Here we provide an overview of posttranslational modifications that are associated with murine and human TALE-homeodomain proteins and discuss their possible importance for the biology of these TFs.
KW  - homeodomain protein
KW  - PTM
KW  - protein phosphorylation
KW  - MEIS
KW  - PBX
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61075
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-610751
SN  - 2296-634X
VL  - 9
IS  - art. 366
SP  - 1
EP  - 10
PB  - Frontiers Media
CY  - Lausanne
ER  -