TY  - JOUR
A1  - Turk, Tom
A1  - Ambrožič Avguštin, Jerneja
A1  - Batista, Urška
A1  - Strugar, Gašper
A1  - Kosmina, Rok
A1  - Čivović, Sandra
A1  - Janussen, Dorte
A1  - Kauferstein, Silke
A1  - Mebs, Dietrich
A1  - Sepčić, Kristina
T1  - Biological activities of ethanolic extracts from deep-sea antarctic marine sponges
T2  - Marine drugs
N2  - We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling.
KW  - Antarctic marine sponges
KW  - hemolysis
KW  - antibacterial activity
KW  - acetylcholinesterase inhibition
KW  - cytotoxicity
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26347
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-263470
SN  - 1660-3397
N1  - © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 11
IS  - 4
SP  - 1126
EP  - 1139
PB  - Molecular Diversity Preservation Internat.
CY  - Basel
ER  -