TY  - JOUR
A1  - Kiesel, Ludwig
A1  - Eichbaum, Christine
A1  - Baumeier, Ariane
A1  - Eichbaum, Michael
T1  - Obesity epidemic - the underestimated risk of endometrial cancer
T2  - Cancers
N2  - Simple Summary

Endometrial cancer is the most frequent gynecologic tumor in developed countries. Obesity is an established risk factor for this disease. This work provides an overview of pathophysiological interactions and pathways in obese women initiating tumorigenesis. Furthermore, the clinical impact of adiposity on the treatment of endometrial cancer is discussed as well therapeutic and preventive options.

Abstract

Endometrial cancer (EC) is the most frequently observed malignant gynecologic disease in developed countries. There is a strong association between the established risk factor obesity and the incidence of EC. Furthermore, the rate of women with a body mass index (BMI) > 30 kg/m2 is increasing worldwide, correspondingly leading to a higher prevalence of EC. Understanding the adipose tissue as an endocrine organ, elementary pathophysiological pathways of tumorigenesis have been revealed. This includes the fundamental role of hyperglycemia, insulin resistance, and hyperestrogenemia, as well as interactions with a chronic proinflammatory microenvironment. Therapeutic options potentially include metformin or bariatric surgery. Moreover, changes in individual lifestyle such as weight reduction, physical activity, and an awareness of healthy nutrition are effective in preventing the disease.
KW  - endometrial cancer
KW  - obesity
KW  - body mass index
KW  - hyperglycemia
KW  - proinflammatory microenvironment
KW  - metformin
KW  - surgery
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57218
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-572186
SN  - 2072-6694
VL  - 12
IS  - Article 3860
PB  - MDPI
CY  - Basel
ER  -