TY  - JOUR
A1  - Nöth, Ulrike
A1  - Tichy, Julia Frederike
A1  - Tritt, Stephanie
A1  - Bähr, Roy Oliver
A1  - Deichmann, Ralf
A1  - Hattingen, Elke
T1  - Quantitative T1 mapping indicates tumor infiltration beyond the enhancing part of glioblastomas
T2  - NMR in Biomedicine
N2  - The aim of this study was to evaluate whether maps of quantitative T1 (qT1) differences induced by a gadolinium‐based contrast agent (CA) are better suited than conventional T1‐weighted (T1w) MR images for detecting infiltration inside and beyond the peritumoral edema of glioblastomas. Conventional T1w images and qT1 maps were obtained before and after gadolinium‐based CA administration in 33 patients with glioblastoma before therapy. The following data were calculated: (i) absolute qT1‐difference maps (qT1 pre‐CA ‐ qT1 post‐CA), (ii) relative qT1‐difference maps, (iii) absolute and (iv) relative differences of conventional T1w images acquired pre‐ and post‐CA. The values of these four datasets were compared in four different regions: (a) the enhancing tumor, (b) the peritumoral edema, (c) a 5 mm zone around the pathology (defined as the sum of regions a and b), and (d) the contralateral normal appearing brain tissue. Additionally, absolute qT1‐difference maps (displayed with linear gray scaling) were visually compared with respective conventional difference images. The enhancing tumor was visible both in the difference of conventional pre‐ and post‐CA T1w images and in the absolute qT1‐difference maps, whereas only the latter showed elevated values in the peritumoral edema and in some cases even beyond. Mean absolute qT1‐difference values were significantly higher (P < 0.01) in the enhancing tumor (838 ± 210 ms), the peritumoral edema (123 ± 74 ms) and in the 5 mm zone around the pathology (81 ± 31 ms) than in normal appearing tissue (32 ± 35 ms). In summary, absolute qT1‐difference maps—in contrast to the difference of T1w images—of untreated glioblastomas appear to be able to visualize CA leakage, and thus might indicate tumor cell infiltration in the edema region and beyond. Therefore, the absolute qT1‐difference maps are potentially useful for treatment planning.
KW  - gadolinium‐based contrast agent
KW  - glioblastoma
KW  - infiltration
KW  - longitudinal relaxation time T1
KW  - quantitative MRI
KW  - quantitative T1‐difference maps
KW  - edema
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57191
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-571916
SN  - 1099-1492
VL  - 33
IS  - 3, e4242
PB  - Wiley
CY  - New York, NY
ER  -