TY  - INPR
A1  - Blanco Rodríguez, Rodolfo Guadalupe
A1  - Du, Xin
A1  - Hernández-Vargas, Esteban A.
T1  - Untangling the cell immune response dynamic for severe and critical cases of SARS-CoV-2 infection
T2  - bioRxiv
N2  - COVID-19 is a global pandemic leading high death tolls worldwide day by day. Clinical evidence suggests that COVID-19 patients can be classified as non-severe, severe and critical cases. In particular, studies have highlighted the relationship between the lymphopenia and the severity of the illness, where CD8+ T cells have the lowest levels in critical cases. In this work, we aim to elucidate the key parameters that define the course of the disease deviating from severe to critical case. To this end, several mathematical models are proposed to represent the dynamic of the immune response in patients with SARS-CoV-2 infection. The best model had a good fit to reported experimental data, and in accordance with values found in the literature. Our results suggest that a rapid proliferation of CD8+ T cells is decisive in the severity of the disease.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - Immune Response
KW  - ODEs
KW  - Mathematical Modeling
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72875
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-728754
IS  - 2021.03.23.436686
ER  -