TY  - JOUR
A1  - Schäfer, Beat W.
A1  - Koscielniak, Ewa
A1  - Kovar, Heinrich
A1  - Fulda, Simone
T1  - ESF-EMBO symposium "molecular biology and innovative therapies in sarcomas of childhood and adolescence" Sept 29–Oct 4, Polonia Castle Pultusk, Poland
T2  - Frontiers in oncology
N2  - Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic characteristic, namely a specific chromosomal translocation (Helman and Meltzer, 2003; Lessnick and Ladanyi, 2012). These translocations generate fusion proteins, which are composed of two transcription factors (TF). Typically, one TF is a developmentally regulated factor that is essential for proper specification of a given lineage and provides the DNA-binding domain, while the partner TF contributes a transactivation domain that drives aberrant expression of target genes. Based on these common genetic characteristics, the first ESF-EMBO research conference entitled “Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence” with special focus on RMS and ES was held at the Polonia Castle in Pultusk, Poland. The conference gathered 70 participants from more than 15 countries and several continents representing most research groups that are active in this field.
KW  - Rhabdomyosarcoma
KW  - Ewing sarcoma
KW  - therapeutics
KW  - PAX3/FOXO1
KW  - EWS/Fli1
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30098
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-300980
SN  - 2234-943X
N1  - Copyright: © 2013 Schäfer, Koscielniak, Kovar and Fulda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
VL  - 3
IS  - Article 142
PB  - Frontiers Media
CY  - Lausanne
ER  -