TY  - JOUR
A1  - Wahn, Volker
A1  - Aberer, Werner
A1  - Eberl, Wolfgang
A1  - Faßhauer, Maria
A1  - Kühne, Thomas
A1  - Kurnik, Karin
A1  - Magerl, Markus
A1  - Meyer-Olson, Dirk
A1  - Martinez Saguer, Inmaculada
A1  - Späth, Peter J.
A1  - Staubach-Renz, Petra
A1  - Kreuz, Wolfhart
T1  - Hereditary angioedema (HAE) in children and adolescents : a consensus on therapeutic strategies
T2  - European journal of pediatrics
N2  - Hereditary angioedema due to C1 inhibitor (C1 esterase inhibitor) deficiency (types I and II HAE-C1-INH) is a rare disease that usually presents during childhood or adolescence with intermittent episodes of potentially life-threatening angioedema. Diagnosis as early as possible is important to avoid ineffective therapies and to properly treat swelling attacks. At a consensus meeting in June 2011, pediatricians and dermatologists from Germany, Austria, and Switzerland reviewed the currently available literature, including published international consensus recommendations for HAE therapy across all age groups. Published recommendations cannot be unconditionally adopted for pediatric patients in German-speaking countries given the current approval status of HAE drugs. This article provides an overview and discusses drugs available for HAE therapy, their approval status, and study results obtained in adult and pediatric patients. Recommendations for developing appropriate treatment strategies in the management of HAE in pediatric patients in German-speaking countries are provided.Conclusion Currently, plasma-derived C1 inhibitor concentrate is considered the best available option for the treatment of acute HAE-C1-INH attacks in pediatric patients in German-speaking countries, as well as for short-term and long-term prophylaxis.
KW  - C1-INH (C1 inhibitor, C1-esterase inhibitor)
KW  - Hereditary angioedema
KW  - Consensus
KW  - Pediatric
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31721
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-317211
SN  - 1432-1076
SN  - 0340-6199
N1  - Copyright © The Author(s) 2012. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
VL  - 171
SP  - 1339
EP  - 1348
PB  - Springer Science & Business Media B.V.
CY  - Berlin ; Dordrecht
ER  -