TY  - JOUR
A1  - Seitz, Oliver
A1  - Schürmann, Christoph
A1  - Hermes, Nadine
A1  - Müller, Elke
A1  - Pfeilschifter, Josef
A1  - Frank, Stefan
A1  - Goren, Itamar
T1  - Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes : a comparative study
T2  - Experimental diabetes research
N2  - In the past, the genetically diabetic-obese diabetes/diabetes (db/db) and obese/obese (ob/ob) mouse strains were used to investigate mechanisms of diabetes-impaired wound healing. Here we determined patterns of skin repair in genetically normal C57Bl/6J mice that were fed using a high fat diet (HFD) to induce a diabetes-obesity syndrome. Wound closure was markedly delayed in HFD-fed mice compared to mice which had received a standard chow diet (CD). Impaired wound tissue of HFD mice showed a marked prolongation of wound inflammation. Expression of vascular endothelial growth factor (VEGF) was delayed and associated with the disturbed formation of wound margin epithelia and an impaired angiogenesis in the reduced granulation tissue. Normal wound contraction was retarded and disordered. Wound disorders in obese C57Bl/6J mice were paralleled by a prominent degradation of the inhibitor of NFκB (IκB-α) in the absence of an Akt activation. By contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair. Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/24175
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-241752
SN  - 1687-5303
SN  - 1687-5214
N1  - Copyright © 2010 Oliver Seitz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2010
IS  - Art. 476969
SP  - 1
EP  - 15
PB  - Hindawi
CY  - New York, NY [u. a.]
ER  -