TY  - JOUR
A1  - Maawi, Sarah al-
A1  - Becker, Kathrin
A1  - Schwarz, Frank
A1  - Sader, Robert Alexander
A1  - Ghanaati, Shahram Michael
T1  - Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review
T2  - International journal of implant dentistry
N2  - Purpose: To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment?
Methods: After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included.
Results: 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing.
Conclusions: Based on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.
KW  - PRF
KW  - Platelet-rich fibrin
KW  - Socket preservation
KW  - Ridge preservation
KW  - Socket healing
KW  - Pain management
KW  - Soft tissue healing
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69556
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-695562
SN  - 2198-4034
N1  - Open Access funding enabled and organized by Projekt DEAL. This study was self-funded by the author.
VL  - 7
IS  - art. 117
SP  - 1
EP  - 27
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -