TY - JOUR A1 - Elke, Gunnar A1 - Bloos, Frank A1 - Wilson, Darius Cameron A1 - Meybohm, Patrick T1 - Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores T2 - Critical care N2 - An early identification of sepsis patients likely to progress towards multiple organ failure is crucial in order to initiate targeted therapeutic strategies to decrease mortality. Our recent publication highlighted the greater accuracy of mid-regional proadrenomedullin (MR-proADM) compared with conventional biomarkers and clinical scores in predicting 28-day mortality in patients with initially low (≤7 points; N = 240) or moderate (8–13 points; N = 653) Sepsis-related Organ Failure Assessment (SOFA) scores, thus confirming results from smaller investigations. This additional post hoc analysis aimed to further describe the non-surviving patient population of both subgroups and identify those likely to progress towards sepsis-related multiple organ failure. ... Y1 - 2018 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46609 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-466094 SN - 1466-609X SN - 1364-8535 N1 - Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. VL - 22 IS - 1, Art. 147 SP - 1 EP - 3 PB - BioMed Central ; Springer CY - London ; Berlin ; Heidelberg ER -