TY  - JOUR
A1  - Klionsky, Daniel
A1  - Petroni, Giulia
A1  - Amaravadi, Ravi K.
A1  - Baehrecke, Eric H.
A1  - Ballabio, Andrea
A1  - Boya, Patricia
A1  - Bravo-San Pedro, José Manuel
A1  - Cadwell, Ken
A1  - Cecconi, Francesco
A1  - Choi, Augustine M. K.
A1  - Choi, Mary E.
A1  - Chu, Charleen T.
A1  - Codogno, Patrice
A1  - Colombo, Maria Isabel
A1  - Cuervo, Ana Maria
A1  - Deretic, Vojo
A1  - Đikić, Ivan
A1  - Elazar, Zvulun
A1  - Eskelinen, Eeva-Liisa
A1  - Fimia, Gian Maria
A1  - Gewirtz, David A.
A1  - Green, Douglas R.
A1  - Hansen, Malene
A1  - Jäättelä, Marja
A1  - Johansen, Terje
A1  - Juhász, Gábor
A1  - Karantza, Vassiliki
A1  - Kraft, Claudine
A1  - Kroemer, Guido
A1  - Ktistakis, Nicholas T.
A1  - Kumar, Sharad
A1  - López Otín, Carlos
A1  - Macleod, Kay F.
A1  - Madeo, Frank
A1  - Martinez, Jennifer
A1  - Meléndez, Alicia
A1  - Mizushima, Noboru
A1  - Münz, Christian
A1  - Penninger, Josef Martin
A1  - Perera, Rushika M.
A1  - Piacentini, Mauro
A1  - Reggiori, Fulvio
A1  - Rubinsztein, David C.
A1  - Ryan, Kevin M.
A1  - Sadoshima, Junichi
A1  - Santambrogio, Laura
A1  - Scorrano, Luca
A1  - Simon, Hans-Uwe
A1  - Simon, Anna Katharina
A1  - Simonsen, Anne
A1  - Stolz, Alexandra
A1  - Tavernarakis, Nektarios
A1  - Tooze, Sharon A.
A1  - Yoshimori, Tamotsu
A1  - Yuan, Junying
A1  - Yue, Zhenyu
A1  - Zhong, Qing
A1  - Galluzzi, Lorenzo
A1  - Pietrocola, Federico
T1  - Autophagy in major human diseases
T2  - The EMBO journal
N2  - Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
KW  - aging
KW  - cancer
KW  - inflammation
KW  - metabolic syndromes
KW  - neurodegeneration
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63905
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-639054
SN  - 1460-2075
VL  - 40
IS  - 19, e108863
SP  - 1
EP  - 63
PB  - EMBO Press ; Wiley
CY  - Heidelberg ; Hoboken, NJ [u.a.]
ER  -