TY  - JOUR
A1  - Gerhardt, Sarah
A1  - Luderer, Mathias
A1  - Bumb, Jan Malte
A1  - Sobanski, Esther
A1  - Moggi, Franz
A1  - Kiefer, Falk
A1  - Vollstädt-Klein, Sabine
T1  - Stop what you're doing! - an fMRI study on comparisons of neural subprocesses of response inhibition in ADHD and alcohol use disorder
T2  - Frontiers in psychiatry
N2  - Rationale: Both attention deficit-/hyperactivity disorder (ADHD) and alcohol use disorder (AUD) are accompanied by deficits in response inhibition. Furthermore, the prevalence of comorbidity of ADHD and AUD is high. However, there is a lack of research on whether the same neuronal subprocesses of inhibition (i.e., interference inhibition, action withholding and action cancellation) exhibit deficits in both psychiatric disorders. Methods: We examined these three neural subprocesses of response inhibition in patient groups and healthy controls: non-medicated individuals with ADHD (ADHD; N = 16), recently detoxified and abstinent individuals with alcohol use disorder (AUD; N = 15), and healthy controls (HC; N = 15). A hybrid response inhibition task covering interference inhibition, action withholding, and action cancellation was applied using a 3T functional magnetic resonance imaging (fMRI). Results: Individuals with ADHD showed an overall stronger hypoactivation in attention related brain areas compared to AUD or HC during action withholding. Further, this hypoactivation was more accentuated during action cancellation. Individuals with AUD recruited a broader network, including the striatum, compared to HC during action withholding. During action cancellation, however, they showed hypoactivation in motor regions. Additionally, specific neural activation profiles regarding group and subprocess became apparent. Conclusions: Even though deficits in response inhibition are related to both ADHD and AUD, neural activation and recruited networks during response inhibition differ regarding both neuronal subprocesses and examined groups. While a replication of this study is needed in a larger sample, the results suggest that tasks have to be carefully selected when examining neural activation patterns of response inhibition either in research on various psychiatric disorders or transdiagnostic questions.
KW  - ADHD
KW  - alcohol use disorder
KW  - response inhibition
KW  - inhibitory control
KW  - fMRI
KW  - impulsivity
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64560
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-645603
SN  - 1664-0640
N1  - This project was supported in part by grants from the Deutsche Forschungsgemeinschaft (TRR 265 Project ID-402170461, Project ID-421888313, Project-ID 437718741, and GRK2350-1 Project-ID 324164820).
VL  - 12
IS  - art. 691930
SP  - 1
EP  - 16
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -