TY  - JOUR
A1  - Jianguang, Ni
A1  - Wunderle, Thomas
A1  - Lewis, Christopher Murphy
A1  - Desimone, Robert
A1  - Diester, Ilka
A1  - Fries, Pascal
T1  - Gamma-rhythmic gain modulation
T2  - Neuron
N2  - Cognition requires the dynamic modulation of effective connectivity, i.e., the modulation of the postsynaptic neuronal response to a given input. If postsynaptic neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized to phases of high gain benefit from enhanced effective connectivity. We show that visually induced gamma-band activity in awake macaque area V4 rhythmically modulates responses to unpredictable stimulus events. This modulation exceeded a simple additive superposition of a constant response onto ongoing gamma-rhythmic firing, demonstrating the modulation of multiplicative gain. Gamma phases leading to strongest neuronal responses also led to shortest behavioral reaction times, suggesting functional relevance of the effect. Furthermore, we find that constant optogenetic stimulation of anesthetized cat area 21a produces gamma-band activity entailing a similar gain modulation. As the gamma rhythm in area 21a did not spread backward to area 17, this suggests that postsynaptic gamma is sufficient for gain modulation.
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73327
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-733279
SN  - 0896-6273
VL  - 92
SP  - 240
EP  - 251
PB  - Cell Press
CY  - [Cambridge, Mass.]
ER  -