TY  - JOUR
A1  - Müller-von der Grün, Jens
A1  - Winkelmann, Anne Ria
A1  - Rödel, Franz
A1  - Balster, Sven
A1  - Neumayer, Thomas Peter Michael
A1  - Ghanaati, Shahram Michael
A1  - Brandts, Christian Hubertus
A1  - Burck, Iris
A1  - Martin, Daniel
A1  - Rödel, Claus
A1  - Kesar, Nikolina
A1  - Balermpas, Panagiotis
T1  - Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center
T2  - European archives of oto-rhino-laryngology and head & neck
N2  - Background; Salivary gland carcinomas (SGC) cover a heterogeneous group of malignancies with a lack of data of high-level evidence.
Methods; Clinical data of 127 patients treated for SGC at a university cancer center between 2002 and 2017 were analyzed retrospectively. The association of clinicopathological characteristics, treatment modalities, adverse events, and outcome was assessed.
Results: Patients received surgery (n = 65), surgery followed by (chemo-)radiotherapy (n = 56), or primary (chemo-)radiotherapy (n = 6). Injury to the cranial nerves or their branches was the most frequent surgical complication affecting 40 patients (33.1%). Ten year overall and progression-free survival rates were 73.2% and 65.4%, respectively. Parotid tumor site, advanced tumor, and positive nodal stage remained independent negative prognostic factors for overall survival, loco-regional and distant tumor control in multivariate analysis.
Conclusions: Optimizing treatment strategies for SGC, depending on distinct clinicopathological factors, remains challenging due to the low incidence rates of the disease.
KW  - Salivary gland carcinoma
KW  - Head and neck cancer
KW  - Surgery
KW  - Radiotherapy
KW  - Patterns of care
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63740
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-637408
SN  - 1434-4726
N1  - This work was supported by grants from the Else Kröner-Fresenius-Stiftung to Jens von der Grün. Open Access funding enabled and organized by Projekt DEAL.
VL  - 278
IS  - 11
SP  - 4411
EP  - 4421
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -