TY  - JOUR
A1  - Hladek, Luca
A1  - Bankov, Katrin
A1  - Müller-von der Grün, Jens
A1  - Filmann, Sonja Natalie
A1  - Demes, Melanie Christin
A1  - Vallo, Stefan
A1  - Wild, Peter Johannes
A1  - Winkelmann, Anne Ria
T1  - Tumor-associated immune cell infiltrate density in penile squamous cell carcinomas
T2  - Virchows Archiv
N2  - Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapted to the individual patient. Fifty-five therapy naïve squamous cell carcinomas, age range between 41 and 85 years with known clinicopathological data, were investigated with the use of tissue microarrays (TMA) regarding the tumor-associated immune cell infiltrate density (ICID). Slides were stained with antibodies against CD3, CD8 and CD20. An image analysis software was applied for evaluation. Data were correlated with clinicopathological characteristics and overall survival. There was a significant increase of ICID in squamous cell carcinomas of the penis in relation to tumor adjacent physiological tissue. Higher CD3-positive ICID was significantly associated with lower tumor stage in our cohort. The ICID was not associated with overall survival. Our data sharpens the view on tumor-associated immune cell infiltrate in penile squamous cell carcinomas with an unbiased digital and automated cell count. Further investigations on the immune cell infiltrate and its prognostic and possible therapeutic impact are needed.
KW  - Penile carcinomas
KW  - Tumor microenvironment
KW  - Tissue microarray
KW  - Antibodies
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69619
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-696192
SN  - 1432-2307
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 480
IS  - 6
SP  - 1159
EP  - 1169
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -