TY  - JOUR
A1  - Golub, Yulia
A1  - Stonawski, Valeska
A1  - Plank, Anne C.
A1  - Eichler, Anna
A1  - Kratz, Oliver
A1  - Waltes, Regina
A1  - Hörsten, Stephan von
A1  - Rößner, Veit
A1  - Freitag, Christine M.
T1  - Anxiety is associated with DPPIV alterations in children with selective mutism and social anxiety disorder: a pilot study
T2  - Frontiers in psychiatry
N2  - Background: Both selective mutism (SM) and social anxiety disorder (SAD) are severe pediatric anxiety disorders with the common trait of behavioral inhibition (BI). The underlying pathophysiology of these disorders remains poorly understood, however converging evidence suggests that alterations in several peripheral molecular pathways might be involved. In a pilot study, we investigated alterations in plasma molecular markers (dipeptidyl peptidase-4 [DPPIV], interleukin-6 [IL-6], tumor necrosis factor-β [TNF-β] and neuropeptide-Y [NPY]) in children with SM, SAD, and healthy controls, as well as the correlation of these markers to symptom severity. Methods: We included 51 children and adolescents (aged 5–18 years; n = 29 girls): n = 20 children in the SM-, n = 16 in the SAD- and n = 15 in the control-group (CG). Peripheral blood samples were analyzed for DPPIV, IL-6, TNF-β, and NPY concentrations. Diverse psychometric measures were used for BI, anxiety, and mutism symptoms. Results: Lower DPPIV-levels were correlated with more anxiety symptoms. However, we could not find a difference in any molecular marker between the patients with SAD and SM in comparison to the CG. Conclusion: DPPIV is proposed as relevant marker for child and adolescent anxiety. Investigating the pathophysiology of SM and SAD focusing on state and trait variables as anxiety or BI might help better understanding the underlying mechanisms of these disorders. Further studies with especially larger cohorts are needed to validate the current pilot-findings.
KW  - anxiety
KW  - behavioral inhibition
KW  - mutism
KW  - social anxiety
KW  - DPPIV
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62021
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-620211
SN  - 1664-0640
VL  - 12
IS  - art. 644553
SP  - 1
EP  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -