TY  - JOUR
A1  - Flinspach, Armin Niklas
A1  - Booke, Hendrik
A1  - Zacharowski, Kai
A1  - Balaban, Ümniye
A1  - Herrmann, Eva
A1  - Adam, Elisabeth
T1  - Associated factors of high sedative requirements within patients with moderate to severe COVID-19 ARDS
T2  - Journal of Clinical Medicine
N2  - The coronavirus pandemic continues to challenge global healthcare. Severely affected patients are often in need of high doses of analgesics and sedatives. The latter was studied in critically ill coronavirus disease 2019 (COVID-19) patients in this prospective monocentric analysis. COVID-19 acute respiratory distress syndrome (ARDS) patients admitted between 1 April and 1 December 2020 were enrolled in the study. A statistical analysis of impeded sedation using mixed-effect linear regression models was performed. Overall, 114 patients were enrolled, requiring unusual high levels of sedatives. During 67.9% of the observation period, a combination of sedatives was required in addition to continuous analgesia. During ARDS therapy, 85.1% (n = 97) underwent prone positioning. Veno-venous extracorporeal membrane oxygenation (vv-ECMO) was required in 20.2% (n = 23) of all patients. vv-ECMO patients showed significantly higher sedation needs (p < 0.001). Patients with hepatic (p = 0.01) or renal (p = 0.01) dysfunction showed significantly lower sedation requirements. Except for patient age (p = 0.01), we could not find any significant influence of pre-existing conditions. Age, vv-ECMO therapy and additional organ failure could be demonstrated as factors influencing sedation needs. Young patients and those receiving vv-ECMO usually require increased sedation for intensive care therapy. However, further studies are needed to elucidate the causes and mechanisms of impeded sedation.
KW  - acute respiratory distress syndrome
KW  - critical care
KW  - hypnotics and sedatives
KW  - severe acute respiratory syndrome coronavirus 2
KW  - pulmonary ventilation
KW  - prone position
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/80031
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-800313
N1  - Data cannot be shared publicly. The datasets generated and/or analyzed during the current study are not publicly available due to national data protection laws but are available upon reasonable request from the corresponding author, or via the data protection officer of the University Hospital Frankfurt (Datenschutz@kgu.de).
VL  - 11
IS  - 3, art. 588
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  -