TY  - JOUR
A1  - Eckes, Timon Sebastian
A1  - Patyna, Ralf Sammy
A1  - Koch, Alexander
A1  - Oftring, Anke
A1  - Gauer, Stefan
A1  - Obermüller, Nicholas
A1  - Schwalm, Stephanie
A1  - Schäfer, Liliana
A1  - Chun, Jerold
A1  - Gröne, Hermann-Josef
A1  - Pfeilschifter, Josef
T1  - Sphingosine 1-phosphate receptor 5 (S1P5) knockout ameliorates adenine-induced nephropathy
T2  - International journal of molecular sciences
N2  - S1P and its receptors have been reported to play important roles in the development of renal fibrosis. Although S1P5 has barely been investigated so far, there are indications that it can influence inflammatory and fibrotic processes. Here, we report the role of S1P5 in renal inflammation and fibrosis. Male S1P5 knockout mice and wild-type mice on a C57BL/6J background were fed with an adenine-rich diet for 7 days or 14 days to induce tubulointerstitial fibrosis. The kidneys of untreated mice served as respective controls. Kidney damage, fibrosis, and inflammation in kidney tissues were analyzed by real-time PCR, Western blot, and histological staining. Renal function was assessed by plasma creatinine ELISA. The S1P5 knockout mice had better renal function and showed less kidney damage, less proinflammatory cytokine release, and less fibrosis after 7 days and 14 days of an adenine-rich diet compared to wild-type mice. S1P5 knockout ameliorates tubular damage and tubulointerstitial fibrosis in a model of adenine-induced nephropathy in mice. Thus, targeting S1P5 might be a promising goal for the pharmacological treatment of kidney diseases.
KW  - sphingolipids
KW  - lysophospholipids
KW  - S1P
KW  - S1P5
KW  - S1PR5
KW  - fibrosis
KW  - nephropathy
KW  - renal inflammation
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/80416
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-804164
SN  - 1422-0067
N1  - This work was supported by the German Research Foundation (SFB 1039 to J.P. and L.S.) and Jackstädt-Stiftung (to A.K.).
VL  - 23
IS  - 7, art. 3952
SP  - 1
EP  - 16
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -