TY  - INPR
A1  - Ali, Tamer
A1  - Rogala, Sandra
A1  - Melissari, Maria-Theodora
A1  - Währisch, Sandra
A1  - Herrmann, Bernhard
A1  - Grote, Phillip
T1  - Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development
T2  - bioRxiv
N2  - Long non-coding RNAs are a very versatile class of molecules that can have important roles in regulating a cells function, including regulating other genes on the transcriptional level. One of these mechanisms is that RNA can directly interact with DNA thereby recruiting additional components such as proteins to these sites via a RNA:dsDNA triplex formation. We genetically deleted the triplex forming sequence (FendrrBox) from the lncRNA Fendrr in mice and find that this FendrrBox is partially required for Fendrr function in vivo. We find that the loss of the triplex forming site in developing lungs causes a dysregulation of gene programs, associated with lung fibrosis. A set of these genes contain a triplex site directly at their promoter and are expressed in fibroblasts. We find that Fendrr with the Wnt signaling pathway regulates these genes, implicating that Fendrr synergizes with Wnt signaling in lung fibrosis.
KW  - 26 LncRNA
KW  - Fendrr
KW  - triplex
KW  - lung development
KW  - Wnt
KW  - fibroblasts
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/74503
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-745033
UR  - https://www.biorxiv.org/content/10.1101/2021.11.02.466973v1
IS  - 2021.11.02.466973 Version 1
PB  - bioRxiv
ER  -