TY - JOUR A1 - Depprich, Rita A1 - Zipprich, Holger A1 - Ommerborn, Michelle A1 - Mahn, Eduardo A1 - Lammers, Lydia A1 - Handschel, Jörg A1 - Naujoks, Christian A1 - Wiesmann, Hans-Peter A1 - Kübler, Norbert A1 - Meyer, Ulrich T1 - Osseointegration of zirconia implants : an SEM observation of the bone-implant interface T2 - Head & face medicine N2 - Background The successful use of zirconia ceramics in orthopedic surgery led to a demand for dental zirconium-based implant systems. Because of its excellent biomechanical characteristics, biocompatibility, and bright tooth-like color, zirconia (zirconium dioxide, ZrO2) has the potential to become a substitute for titanium as dental implant material. The present study aimed at investigating the osseointegration of zirconia implants with modified ablative surface at an ultrastructural level. Methods A total of 24 zirconia implants with modified ablative surfaces and 24 titanium implants all of similar shape and surface structure were inserted into the tibia of 12 Gottinger minipigs. Block biopsies were harvested 1 week, 4 weeks or 12 weeks (four animals each) after surgery. Scanning electron microscopy (SEM) analysis was performed at the bone implant interface. Results Remarkable bone attachment was already seen after 1 week which increased further to intimate bone contact after 4 weeks, observed on both zirconia and titanium implant surfaces. After 12 weeks, osseointegration without interposition of an interfacial layer was detected. At the ultrastructural level, there was no obvious difference between the osseointegration of zirconia implants with modified ablative surfaces and titanium implants with a similar surface topography. Conclusion The results of this study indicate similar osseointegration of zirconia and titanium implants at the ultrastructural level. Y1 - 2008 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6048 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30-60217 SN - 1746-160X N1 - © 2008 Depprich et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. VL - 4 IS - Art. 25 SP - 1 EP - 7 PB - BioMed Central CY - London ER -