TY  - JOUR
A1  - Brinkmann, Vanessa
A1  - Romeo, Margherita
A1  - Larigot, Lucie
A1  - Hemmers, Anne
A1  - Tschage, Lisa
A1  - Kleinjohann, Jennifer
A1  - Schiavi, Alfonso
A1  - Steinwachs, Swantje
A1  - Esser, Charlotte
A1  - Menzel, Ralph
A1  - Giani Tagliabue, Sara
A1  - Bonati, Laura
A1  - Cox, Fiona
A1  - Ale-Agha, Niloofar
A1  - Jakobs, Philipp
A1  - Altschmied, Joachim
A1  - Haendeler, Judith
A1  - Coumoul, Xavier
A1  - Ventura, Natascia
T1  - Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects
T2  - Antioxidants
N2  - The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how the AhR mediates the anti-aging effects of curcumin across species. Using a combination of in vivo, in vitro, and in silico analyses, we demonstrated that curcumin has AhR-dependent or -independent effects in a context-specific manner. We found that in Caenorhabditis elegans, AhR mediates curcumin-induced lifespan extension, most likely through a ligand-independent inhibitory mechanism related to its antioxidant activity. Curcumin also showed AhR-independent anti-aging activities, such as protection against aggregation-prone proteins and oxidative stress in C. elegans and promotion of the migratory capacity of human primary endothelial cells. These AhR-independent effects are largely mediated by the Nrf2/SKN-1 pathway.
KW  - aryl hydrocarbon receptor
KW  - curcumin
KW  - oxidative stress
KW  - Caenorhabditis elegans
KW  - mice
KW  - endothelial cells
KW  - in vivo
KW  - in vitro
KW  - in silico
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/84425
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-844258
SN  - 2076-3921
N1  - Funding: 
DFG ; VE366/6-1
DFG ; VE366/8-1
DFG ; IRTG1902-P1
DFG ; IRTG1902-P2
Jürgen Manchot Foundation
Caenorhabditis Genetics Center
NIH Office of Research Infrastructure Programs ; P40 OD010440
VL  - 11
IS  - 4, art. 613
SP  - 1
EP  - 30
PB  - MDPI
CY  - Basel
ER  -