TY  - JOUR
A1  - Miner, Daniel
A1  - Triesch, Jochen
T1  - Slicing, sampling, and distance-dependent effects affect network measures in simulated cortical circuit structures
T2  - Frontiers in neuroanatomy
N2  - The neuroanatomical connectivity of cortical circuits is believed to follow certain rules, the exact origins of which are still poorly understood. In particular, numerous nonrandom features, such as common neighbor clustering, overrepresentation of reciprocal connectivity, and overrepresentation of certain triadic graph motifs have been experimentally observed in cortical slice data. Some of these data, particularly regarding bidirectional connectivity are seemingly contradictory, and the reasons for this are unclear. Here we present a simple static geometric network model with distance-dependent connectivity on a realistic scale that naturally gives rise to certain elements of these observed behaviors, and may provide plausible explanations for some of the conflicting findings. Specifically, investigation of the model shows that experimentally measured nonrandom effects, especially bidirectional connectivity, may depend sensitively on experimental parameters such as slice thickness and sampling area, suggesting potential explanations for the seemingly conflicting experimental results.
KW  - cortical networks
KW  - graph theory
KW  - nonrandom connectivity
KW  - network topology
KW  - common neighbor
KW  - motifs
KW  - cortical slices
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/35819
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-358192
SN  - 1662-5129
N1  - Copyright © 2014 Miner and Triesch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 8
IS  - Article 125
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -