TY  - JOUR
A1  - Mann, Caroline
A1  - Schäfer, Tim
A1  - Bletsch, Anke
A1  - Gudbrandsen, Maria
A1  - Daly, Eileen
A1  - Suckling, John
A1  - Bullmore, Edward T.
A1  - Lombardo, Michael V.
A1  - Lai, Meng-Chuan
A1  - Craig, Michael C.
A1  - Baron-Cohen, Simon
A1  - Murphy, Declan G. M.
A1  - Ecker, Christine
T1  - Examining volumetric gradients based on the frustum surface ratio in the brain in autism spectrum disorder
T2  - Human brain mapping
N2  - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is accompanied by neurodevelopmental differences in regional cortical volume (CV), and a potential layer‐specific pathology. Conventional measures of CV, however, do not indicate how volume is distributed across cortical layers. In a sample of 92 typically developing (TD) controls and 92 adult individuals with ASD (aged 18–52 years), we examined volumetric gradients by quantifying the degree to which CV is weighted from the pial to the white surface of the brain. Overall, the spatial distribution of Frustum Surface Ratio (FSR) followed the gyral and sulcal pattern of the cortex and approximated a bimodal Gaussian distribution caused by a linear mixture of vertices on gyri and sulci. Measures of FSR were highly correlated with vertex‐wise estimates of mean curvature, sulcal depth, and pial surface area, although none of these features explained more than 76% variability in FSR on their own. Moreover, in ASD, we observed a pattern of predominant increases in the degree of FSR relative to TD controls, with an atypical neurodevelopmental trajectory. Our findings suggest a more outward‐weighted gradient of CV in ASD, which may indicate a larger contribution of supragranular layers to regional differences in CV.
KW  - autism spectrum disorder
KW  - brain anatomy
KW  - computational neuroimaging
KW  - cortical folding
KW  - grey matter volume
KW  - gyrification
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/59010
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-590101
SN  - 1097-0193
SN  - 1065-9471
VL  - 42.2021
IS  - 4
SP  - 953
EP  - 966
PB  - Wiley
CY  - New York, NY
ER  -