TY  - JOUR
A1  - Wandiyanto, Jason V.
A1  - Linklater, Denver
A1  - Perera, Pallale Tharushi
A1  - Orlowska, Anna
A1  - Truong, Vi Khanh
A1  - Thissen, Helmut
A1  - Ghanaati, Shahram Michael
A1  - Baulin, Vladimir
A1  - Crawford, Russell J.
A1  - Juodkazis, Saulius
A1  - Ivanova, Elena P.
T1  - Pheochromocytoma (PC12) cell response on mechanobactericidal titanium surfaces
T2  - Materials
N2  - Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation—a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants.
KW  - mechanobactericidal surfaces
KW  - nanostructures
KW  - titanium
KW  - PC12 cells
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/33818
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-338187
SN  - 1996-1944
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
VL  - 11
IS  - 4, Art. 605
SP  - 1
EP  - 13
PB  - MDPI
CY  - Basel
ER  -