TY  - JOUR
A1  - Oberoi-Khanuja, Tripat Kaur
A1  - Rajalingam, Krishnaraj
T1  - IAPs as E3 ligases of Rac1 : shaping the move
T2  - Small GTPases
N2  - Inhibitors of Apoptosis Proteins (IAPs) are well-studied E3 ubiquitin ligases predominantly known for regulation of apoptosis. We uncovered that IAPs can function as a direct E3 ubiquitin ligase of RhoGTPase Rac1. cIAP1 and XIAP directly conjugate polyubiquitin chains to Lysine 147 of activated Rac1 and target it for proteasomal degradation. Consistently, loss of these IAPs by various strategies led to stabilization of Rac1 and mesenchymal mode of migration in tumor cells. IAPs also regulate Rac1 degradation upon RhoGDI1 depletion and CNF1 toxin treatment. Our observations revealed an evolutionarily conserved role of IAPs in regulating Rac1 stability shedding light on to the mechanisms behind ubiquitination–dependent inactivation of Rac1 signaling.
KW  - E3 ligase
KW  - IAPs
KW  - Proteasome
KW  - Rac1
KW  - RhoA
KW  - RhoGTPases
KW  - Ubiquitination
KW  - XIAP
KW  - amoeboid
KW  - cIAP1
KW  - cell migration
KW  - mesenchymal
KW  - plasticity
KW  - ubiquitin
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28935
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-289354
SN  - 2154-1256
SN  - 2154-1248
N1  - Copyright © 2012 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
VL  - 3
IS  - 2
SP  - 131
EP  - 136
PB  - Landes Bioscience
CY  - Austin, Tex.
ER  -