TY  - JOUR
A1  - Schulz, Michael
A1  - Sevenich, Lisa
T1  - TAMs in brain metastasis: molecular signatures in mouse and man
T2  - Frontiers in immunology
N2  - Macrophages not only represent an integral part of innate immunity but also critically contribute to tissue and organ homeostasis. Moreover, disease progression is accompanied by macrophage accumulation in many cancer types and is often associated with poor prognosis and therapy resistance. Given their critical role in modulating tumor immunity in primary and metastatic brain cancers, macrophages are emerging as promising therapeutic targets. Different types of macrophages infiltrate brain cancers, including (i) CNS resident macrophages that comprise microglia (TAM-MG) as well as border-associated macrophages and (ii) monocyte-derived macrophages (TAM-MDM) that are recruited from the periphery. Controversy remained about their disease-associated functions since classical approaches did not reliably distinguish between macrophage subpopulations. Recent conceptual and technological advances, such as large-scale omic approaches, provided new insight into molecular profiles of TAMs based on their cellular origin. In this review, we summarize insight from recent studies highlighting similarities and differences of TAM-MG and TAM-MDM at the molecular level. We will focus on data obtained from RNA sequencing and mass cytometry approaches. Together, this knowledge significantly contributes to our understanding of transcriptional and translational programs that define disease-associated TAM functions. Cross-species meta-analyses will further help to evaluate the translational significance of preclinical findings as part of the effort to identify candidates for macrophage-targeted therapy against brain metastasis.
KW  - cerebral metastasis
KW  - brain cancer
KW  - tumor microenvironment
KW  - tumor-associated macrophages
KW  - microglia
KW  - tumor immunology
KW  - targeted therapy
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62663
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-626639
SN  - 1664-3224
N1  - Research in the lab of LS is supported by institutional funds from the Georg-Speyer-Haus jointly funded by the German Federal Ministry of Health and the Ministry of Higher Education, Research and the Arts of the State of Hesse (HMWK), as well as grants from the German Cancer Aid (Max-Eder Junior Group Leader Program 70111752) and German Research Foundation (SE2234/3-1).
VL  - 12
IS  - art. 716504
SP  - 1
EP  - 16
PB  - Frontiers Media
CY  - Lausanne
ER  -