TY  - JOUR
A1  - Fumeaux, Thierry
A1  - Berger, Claudia
A1  - Bausch, Alexander
A1  - Wright, Matthew
A1  - Vilimanovich, Urosh
A1  - Soldatovic, Ivan
A1  - Vehreschild, Maria J. G. T.
T1  - The KINETIC phase 2 randomised controlled trial of oral pamapimod-pioglitazone in non-critically ill COVID-19 inpatients
T2  - iScience
N2  - The combination of pamapimod and pioglitazone (KIN001) has a synergetic antiviral, anti-inflammatory, and antifibrotic activity, which may prevent evolution toward COVID-19-associated severe respiratory failure. In a randomized, placebo-controlled, double-blind, phase 2, multicenter trial, 128 non-critically ill hospitalized patients with confirmed COVID-19 were treated with KIN001 or a placebo for 28 days. The proportion of patients alive and free of oxygen or respiratory support at the end of the therapy was lower than anticipated but not different in the two groups (KIN001 n = 19, 29%, placebo n = 21, 33%). 85 participants had at least one adverse event, with no difference in the number and distribution of events between the two groups. The clinical trial was stopped for futility, mainly due to a lower-than-expected incidence of the primary endpoint. KIN001 was safe and well-tolerated but had no significant effect on clinical outcome.
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79147
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-791477
SN  - 2589-0042
VL  - 26
IS  - 108038
SP  - 1
EP  - 9
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -