TY  - INPR
A1  - Shahjouei, Shima
A1  - Tsivgoulis, Georgios
A1  - Farahmand, Ghasem
A1  - Koza, Eric
A1  - Mowla, Ashkan
A1  - Vafaei Sadr, Alireza
A1  - Kia, Arash
A1  - Vaghefi Far, Alaleh
A1  - Mondello, Stefania
A1  - Cernigliaro, Achille
A1  - Ranta, Annemarei
A1  - Punter, Martin
A1  - Khodadadi, Faezeh
A1  - Sabra, Mirna
A1  - Ramezani, Mahtab
A1  - Naderi, Soheil
A1  - Olulana, Oluwaseyi
A1  - Chaudhary, Durgesh
A1  - Lyoubi, Aicha
A1  - Campbell, Bruce
A1  - Arenillas, Juan F.
A1  - Bock, Daniel
A1  - Montaner, Joan
A1  - Aghayari Sheikh Neshin, Saeideh
A1  - Sousa, Diana Aguiar de
A1  - Tenser, Matthew S.
A1  - Aires, Ana
A1  - De Lera Alfonso, Merccedes
A1  - Alizada, Orkhan
A1  - Azevedo, Elsa
A1  - Goyal, Nitin
A1  - Babaeepour, Zabihollah
A1  - Banihashemi, Gelareh
A1  - Bonati, Leo
A1  - Cereda, Carlo
A1  - Chang, Jason J.
A1  - Crnjakovic, Miljenko
A1  - De Marchis, Gian Marco
A1  - Del Sette, Massimo
A1  - Ebrahimzadeh, Seyed Amir
A1  - Farhoudi, Mehdi
A1  - Gandoglia, Ilaria
A1  - Gonçalves, Bruno
A1  - Griessenauer, Christoph J.
A1  - Murat Hancı, Mehmet
A1  - Katsanos, Aristeides H.
A1  - Krogias, Christos
A1  - Leker, Ronen
A1  - Lotman, Lev
A1  - Mai, Jeffrey
A1  - Male, Shailesh
A1  - Malhotra, Konark
A1  - Malojcic, Branko
A1  - Mesquita, Teresa
A1  - Mir Ghasemi, Asadollah
A1  - Aref, Hany Mohamed
A1  - Mohseni Afshar, Zeinab
A1  - Moon, Jusun
A1  - Niemelä, Mika
A1  - Rezaei Jahromi, Behnam
A1  - Nolan, Lawrence
A1  - Pandhi, Abhi
A1  - Park, Jong-Ho
A1  - Pedro Marto, João
A1  - Purroy, Francisco
A1  - Ranji-Burachaloo, Sakineh
A1  - Carreira, Nuno Reis
A1  - Requena, Manuel
A1  - Rubiera del Fueyo, Marta A.
A1  - Sajedi, Seyed Aidin
A1  - Sargento-Freitas, João
A1  - Sharma, Vijay
A1  - Steiner, Thorsten
A1  - Tempro, Kristi
A1  - Turc, Guillaume
A1  - Ahmadzadeh, Yassaman
A1  - Almasi Dooghaee, Mostafa
A1  - Assarzadegan, Farhad
A1  - Babazadeh, Arefeh
A1  - Baharvahdat, Humain
A1  - Cardoso, Fabricio
A1  - Dev, Apoorva
A1  - Ghorbani, Mohammad
A1  - Hamidi, Ava
A1  - Sadat Hasheminejad, Zeynab
A1  - Hojjat-Anasri Komachali, Sahar
A1  - Khorvash, Fariborz
A1  - Kobeissy, Firas
A1  - Mirkarimi, Hamidreza
A1  - Mohammadi-Vosough, Elahe
A1  - Misra, Debdipto
A1  - Reza Noorian, Ali
A1  - Nowrouzi-Sohrabi, Peyman
A1  - Paybast, Sepideh
A1  - Poorsaadat, Leila
A1  - Roozbeh, Mehrdad
A1  - Sabayan, Behnam
A1  - Salehizadeh, Saeideh
A1  - Saberi, Alia
A1  - Sepehrnia, Mercedeh
A1  - Vahabizad, Fahimeh
A1  - Yasuda, Thomas Alexandre
A1  - Hojati Marvast, Ahmadreza
A1  - Ghabaee, Mojdeh
A1  - Rahimian, Nasrin
A1  - Harirchian, Mohammad Hossein
A1  - Borhani Haghighi, Afshin
A1  - Arora, Rohan
A1  - Ansari, Saeed
A1  - Avula, Venkatesh
A1  - Li, Jiang
A1  - Abedi, Vida
A1  - Zand, Ramin
T1  - SARS-CoV-2 and stroke characteristics: a report from the Multinational COVID-19 Stroke Study Group
T2  - medRxiv
N2  - Background: Stroke is reported as a consequence of SARS-CoV-2 infection. However, there is a lack of regarding comprehensive stroke phenotype and characteristics
Methods: We conducted a multinational observational study on features of consecutive acute ischemic stroke (AIS), intracranial hemorrhage (ICH), and cerebral venous or sinus thrombosis (CVST) among SARS-CoV-2 infected patients. We further investigated the association of demographics, clinical data, geographical regions, and countries’ health expenditure among AIS patients with the risk of large vessel occlusion (LVO), stroke severity as measured by National Institute of Health stroke scale (NIHSS), and stroke subtype as measured by the TOAST criteria. Additionally, we applied unsupervised machine learning algorithms to uncover possible similarities among stroke patients.
Results: Among the 136 tertiary centers of 32 countries who participated in this study, 71 centers from 17 countries had at least one eligible stroke patient. Out of 432 patients included, 323(74.8%) had AIS, 91(21.1%) ICH, and 18(4.2%) CVST. Among 23 patients with subarachnoid hemorrhage, 16(69.5%) had no evidence of aneurysm. A total of 183(42.4%) patients were women, 104(24.1%) patients were younger than 55 years, and 105(24.4%) patients had no identifiable vascular risk factors. Among 380 patients who had known interval onset of the SARS-CoV-2 and stroke, 144(37.8%) presented to the hospital with chief complaints of stroke-related symptoms, with asymptomatic or undiagnosed SARS-CoV-2 infection. Among AIS patients 44.5% had LVO; 10% had small artery occlusion according to the TOAST criteria. We observed a lower median NIHSS (8[3-17], versus 11 [5-17]; p=0.02) and higher rate of mechanical thrombectomy (12.4% versus 2%; p<0.001) in countries with middle to high-health expenditure when compared to countries with lower health expenditure. The unsupervised machine learning identified 4 subgroups, with a relatively large group with no or limited comorbidities.
Conclusions: We observed a relatively high number of young, and asymptomatic SARS-CoV-2 infections among stroke patients. Traditional vascular risk factors were absent among a relatively large cohort of patients. Among hospitalized patients, the stroke severity was lower and rate of mechanical thrombectomy was higher among countries with middle to high-health expenditure.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73565
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-735652
IS  - 2020.08.05.20169169
ER  -