TY  - JOUR
A1  - Blessing, Recha
A1  - Ahoopai, Majid
A1  - Geyer, Martin
A1  - Brandt, Moritz
A1  - Zeiher, Andreas M.
A1  - Münzel, Thomas
A1  - Wenzel, Philip
A1  - Gori, Tommaso
A1  - Dimitriadis, Zisis
T1  - The bioengineered combo dual-therapy CD34 antibody-covered sirolimus-eluting coronary stent in patients with chronic total occlusion evaluated by clinical outcome and optical coherence tomography imaging analysis
T2  - Journal of clinical medicine
N2  - We sought to determine the effects of the use of a Bioengineered Combo Dual-Therapy CD34 Antibody-Covered Sirolimus-Eluting Coronary Stent (Combo® DTS) in patients with chronic total occlusion (CTO) by evaluating clinical outcomes and by performing an optical coherence tomography (OCT) analysis. We retrospectively analyzed data from 39 patients who had successfully undergone OCT-guided revascularization of a CTO being treated with a Combo® DTS. Clinical assessment, angiography (with quantitative coronary angiography analysis) and OCT examination were performed at baseline and at follow-up. The median follow-up period was 189 days, ranging from 157 to 615 days. At follow-up, revascularization was required due to angiographic restenosis in 40% (14 of 35) of patients. OCT analysis detected neointima proliferation in 23 (76.6%) patients. Neointima formation was often associated with microvessels in 18 patients (60%). Neoatheroslcerosis was observed in 2 (6.6%) patients. Malapposition was found in 4 patients (13.3%), and stent fractures were found in 11 patients (36.6%). Rate of strut coverage was 96.3% at follow-up. In conclusion, the implantation of a Combo® DTS after successful CTO recanalization was associated with a restenosis rate of 40% despite good stent implantation at baseline, proven by OCT. Neointima formation was found as a main contributor to restenosis. Nevertheless, we observed a low rate of major cardiovascular events in our follow-up.
KW  - Combo® DTS
KW  - chronic total occlusion
KW  - optical coherence tomography
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57476
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-574768
SN  - 2077-0383
VL  - 10.2021
IS  - Article number: 80
PB  - MDPI
CY  - Basel
ER  -