TY  - INPR
A1  - Schommartz, Iryna
A1  - Lembcke, Philip F.
A1  - Schuetz, Henriette
A1  - Wald de Chamorro, Nina
A1  - Bauer, Martin
A1  - Kaindl, Angela M.
A1  - Buß, Claudia
A1  - Shing, Yee Lee
T1  - From learning to remembering: how memory consolidation differs in term and preterm born children from young adults
T2  - bioRxiv
N2  - From early to middle childhood, brain regions that underlie memory consolidation undergo profound maturational changes. However, there is little empirical investigation that directly relates age-related differences in brain structural measures to the memory consolidation processes. The present study examined system-level memory consolidations of intentionally studied object-location associations after one night of sleep (short delay) and after two weeks (long delay) in normally developing 5-to-7-year-old children (n = 50) and young adults (n = 39). Behavioural differences in memory consolidation were related to structural brain measures. Our results showed that children, in comparison to young adults, consolidate correctly learnt object-location associations less robustly over short and long delay. Moreover, using partial least squares correlation method, a unique multivariate profile comprised of specific neocortical (prefrontal, parietal, and occipital), cerebellar, and hippocampal subfield structures was found to be associated with variation in short-delay memory consolidation. A different multivariate profile comprised of a reduced set of brain structures, mainly consisting of neocortical (prefrontal, parietal, and occipital), and selective hippocampal subfield structures (CA1-2 and subiculum) was associated with variation in long-delay memory consolidation. Taken together, the results suggest that multivariate structural pattern of unique sets of brain regions are related to variations in short- and long-delay memory consolidation across children and young adults.
RESEARCH HIGHLIGHTS
Short- and long-delay memory consolidation is less robust in children than in young adults
* Short-delay brain profile comprised of hippocampal, cerebellar, and neocortical brain regions
* Long-delay brain profile comprised of neocortical and selected hippocampal brain regions.
* Brain profiles differ between children and young adults.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/85702
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-857020
UR  - https://www.biorxiv.org/content/10.1101/2021.08.24.457558v1
IS  - 2021.08.24.457558 Version 1
PB  - bioRxiv
ER  -