TY  - JOUR
A1  - Kitz, Richard
A1  - Böhles, Hansjosef
A1  - Rosewich, Martin
A1  - Rose, Markus A.
T1  - Lipid-laden alveolar macrophages and pH monitoring in gastroesophageal reflux-related respiratory symptoms
T2  - Pulmonary medicine
N2  - Lipid-laden alveolar macrophages and pH monitoring have been used in the diagnosis of chronic aspiration in children with gastroesophageal reflux (GER). This study was conducted to prove a correlation between the detection of alimentary pulmonary fat phagocytosis and an increasing amount of proximal gastroesophageal reflux. It was assumed that proximal gastroesophageal reflux better correlates with aspiration than distal GER. Patients from 6 months to 16 years with unexplained recurrent wheezy bronchitis and bronchial hyperreactivity, or recurrent pneumonia with chronic cough underwent 24-hour double-channel pH monitoring and bronchoscopy with bronchoalveolar lavage (BAL). Aspiration of gastric content was determined by counting lipid laden alveolar macrophages from BAL specimens. There were no correlations between any pH-monitoring parameters and counts of lipid-laden macrophages in the whole study population, even when restricting analysis to those with abnormal reflux index expressing clinically significant GER. Quantifying lipid-laden alveolar macrophages from BAL in children with gastroesophageal-related respiratory disorders does not have an acceptable specificity to prove chronic aspiration as an underlying etiology. Therefore, research for other markers of pulmonary aspiration is needed.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/24237
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-242378
SN  - 2090-1844
SN  - 2090-1836
N1  - Copyright © 2012 R. Kitz et al. This is an open access article distributed under the   Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2012
IS  - Article Id 673637
PB  - Hindawi
CY  - New York, NY [u.a.]
ER  -