TY  - JOUR
A1  - O'Dwyer, Laurence
A1  - Lamberton, Franck
A1  - Bokde, Arun L. W.
A1  - Ewers, Michael
A1  - Faluyi, Yetunde O.
A1  - Tanner, Colby
A1  - Mazoyer, Bernard M.
A1  - O'Neill, Des
A1  - Bartley, Máiréad
A1  - Collins, D. Rónán
A1  - Coughlan, Tara
A1  - Prvulovic, David
A1  - Hampel, Harald
T1  - Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease
T2  - PLoS One
N2  - The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, tract-based spatial statistics (TBSS) were performed on scans of 40 healthy elders, 19 non-amnestic MCI (MCIna) subjects, 14 amnestic MCI (MCIa) subjects and 9 AD patients. Significantly higher DA was found in MCIna subjects compared to healthy elders in the right posterior cingulum/precuneus. Significantly higher DA was also found in MCIa subjects compared to healthy elders in the left prefrontal cortex, particularly in the forceps minor and uncinate fasciculus. In the MCIa versus MCIna comparison, significantly higher DA was found in large areas of the left prefrontal cortex. For AD patients, the overlap of FA and DR changes and the overlap of FA and MD changes were seen in temporal, parietal and frontal lobes, as well as the corpus callosum and fornix. Analysis of differences between the AD versus MCIna, and AD versus MCIa contrasts, highlighted regions that are increasingly compromised in more severe disease stages. Microstructural damage independent of gross tissue loss was widespread in later disease stages. Our findings suggest a scheme where WM damage begins in the core memory network of the temporal lobe, cingulum and prefrontal regions, and spreads beyond these regions in later stages. DA and MD indices were most sensitive at detecting early changes in MCIa.
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/22590
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-113196
SN  - 1932-6203
N1  - Copyright: © 2011 O'Dwyer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 6
IS  - (6): e21745
SP  - 1
EP  - 13
PB  - PLoS
CY  - Lawrence, Kan.
ER  -