TY  - JOUR
A1  - Oertel-Knöchel, Viola
A1  - Kraft, Dominik
A1  - Alves, Gilberto Sousa
A1  - Knöchel, Christian
A1  - Ghinea, Denisa
A1  - Storchak, Helena
A1  - Matura, Silke
A1  - Prvulovic, David
A1  - Bittner, Robert Arthur
A1  - Linden, David
A1  - Reif, Andreas
A1  - Stäblein, Michael
T1  - Associative memory impairments are associated with functional alterations within the memory network in schizophrenia patients and their unaffected first-degree relatives : an fMRI study
T2  - Frontiers in psychiatry
N2  - Memory impairments are a major characteristic of schizophrenia (SZ). In the current study, we used an associative memory task to test the hypothesis that SZ patients and first-degree relatives have altered functional patterns in comparison to healthy controls. We analyzed the fMRI activation pattern during the presentation of a face-name task in 27 SZ patients, 23 first-degree relatives, and 27 healthy controls. In addition, we performed correlation analyses between individual psychopathology, accuracy and reaction time of the task and the beta scores of the functional brain activations. We observed a lower response accuracy and increased reaction time during the retrieval of face-name pairs in SZ patients compared with controls. Deficient performance was accompanied by abnormal functional activation patterns predominantly in DMN regions during encoding and retrieval. No significant correlation between individual psychopathology and neuronal activation during encoding or retrieval of face-name pairs was observed. Findings of first-degree relatives indicated slightly different functional pattern within brain networks in contrast to controls without significant differences in the behavioral task. Both the accuracy of memory performance as well as the functional activation pattern during retrieval revealed alterations in SZ patients, and, to a lesser degree, in relatives. The results are of potential relevance for integration within a comprehensive model of memory function in SZ. The development of a neurophysiological model of cognition in psychosis may help to clarify and improve therapeutic options to improve memory and functioning in the illness.
KW  - face-name association task
KW  - associative memory
KW  - schizophrenia
KW  - schizophrenia spectrum
KW  - fMRI
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48876
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-488763
SN  - 1664-0640
N1  - Copyright © 2019 Oertel, Kraft, Alves, Knöchel, Ghinea, Storchak, Matura, Prvulovic, Bittner, Linden, Reif and Stäblein. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 10
IS  - Art. 33
SP  - 1
EP  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -