TY  - JOUR
A1  - Ronellenfitsch, Michael Wilfried
A1  - Luger, Anna-Luisa
A1  - Steinbach, Joachim Peter
T1  - EGFR and mTOR as therapeutic targets in glioblastoma
T2  - OncoTarget
N2  - The quest for new and improved therapies for glioblastoma (GB) has been mostly unsuccessful in more than a decade despite significant efforts. The few exceptions include the optimization of classical alkylating chemotherapy by including lomustine in the first line regimen for GB with a methylated MGMT promoter and tumor treating fields. The GB signaling network has been well-characterized and genetic alterations resulting in activation of receptor tyrosine kinases and especially epidermal growth factor receptor (EGFR) and downstream mammalian target of rapamycin complex 1 (mTORC1) signaling were found in the majority of GBs. ...
KW  - glioblastoma
KW  - EGFR
KW  - mTOR
KW  - DDIT4
KW  - tumor microenvironment
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50761
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-507611
SN  - 1949-2553
N1  - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
VL  - 10
IS  - 46
SP  - 4721
EP  - 4723
PB  - Impact Journals LLC
CY  - [s. l.]
ER  -