TY  - JOUR
A1  - Muellerleile, Julia
A1  - Blistein, Aline
A1  - Rohlmann, Astrid
A1  - Scheiwe, Frederieke
A1  - Missler, Markus
A1  - Schwarzacher, Stephan
A1  - Jedlička, Peter
T1  - Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin
T2  - Scientific reports
N2  - Deletion of the autism candidate molecule neurobeachin (Nbea), a large PH-BEACH-domain containing neuronal protein, has been shown to affect synaptic function by interfering with neurotransmitter receptor targeting and dendritic spine formation. Previous analysis of mice lacking one allele of the Nbea gene identified impaired spatial learning and memory in addition to altered autism-related behaviours. However, no functional data from living heterozygous Nbea mice (Nbea+/−) are available to corroborate the behavioural phenotype. Here, we explored the consequences of Nbea haploinsufficiency on excitation/inhibition balance and synaptic plasticity in the intact hippocampal dentate gyrus of Nbea+/− animals in vivo by electrophysiological recordings. Based on field potential recordings, we show that Nbea+/− mice display enhanced LTP of the granule cell population spike, but no differences in basal synaptic transmission, synapse numbers, short-term plasticity, or network inhibition. These data indicate that Nbea haploinsufficiency causes remarkably specific alterations to granule cell excitability in vivo, which may contribute to the behavioural abnormalities in Nbea+/− mice and to related symptoms in patients.
KW  - Hippocampus
KW  - Long-term potentiation
KW  - Synaptic transmission
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/74349
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-743492
SN  - 2045-2322
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 10
IS  - 1, art. 16058
SP  - 1
EP  - 12
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -