TY  - INPR
A1  - Mallaroni, Pablo
A1  - Mason, Natasha L.
A1  - Kloft, Lilian
A1  - Reckweg, Johannes T.
A1  - Oorsouw, Kim van
A1  - Tönnes, Stefan W.
A1  - Tolle, Hanna M.
A1  - Amico, Enrico
A1  - Ramaekers, Johannes G.
T1  - Ritualistic use of ayahuasca enhances a shared functional connectome identity with others
T2  - bioRxiv
N2  - The knowledge that brain functional connectomes are both unique and reliable has enabled behaviourally relevant inferences at a subject level. However, it is unknown whether such “fingerprints” persist under altered states of consciousness. Ayahuasca is a potent serotonergic psychedelic which elicits a widespread dysregulation of functional connectivity. Used communally in religious ceremonies, its shared use may highlight relevant novel interactions between mental state and FC inherency. Using 7T fMRI, we assessed resting-state static and dynamic FCs for 21 Santo Daime members after collective ayahuasca intake in an acute, within-subject study. Here, connectome fingerprinting revealed a shared functional space, accompanied by a spatiotemporal reallocation of keypoint edges. Importantly, we show that interindividual differences in higher-order FCs motifs are relevant to experiential phenotypes, given that they can predict perceptual drug effects. Collectively, our findings offer an example as to how individualised connectivity markers can be used to trace a subject’s functional connectome across altered states of consciousness.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73102
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-731029
IS  - 2022.10.07.511268
ER  -