TY  - JOUR
A1  - Bink, Diewertje I.
A1  - Pauli, Jessica
A1  - Mägdefessel, Lars
A1  - Boon, Reinier
T1  - Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing
T2  - Atherosclerosis
N2  - Highlights
• Endothelial ageing contributes significantly to atherosclerosis.
• Non-coding RNAs are gaining interest as regulators of vascular biology.
• Several microRNAs regulate endothelial cell ageing.
• Multiple lncRNAs play a role in endothelial cell ageing.
Abstract
Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.
KW  - Endothelial cells
KW  - Ageing
KW  - Non-coding RNA
KW  - lncRNA
KW  - microRNA
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78956
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-789565
SN  - 0021-9150
VL  - 374
SP  - 99
EP  - 106
PB  - Elsevier
CY  - Amsterdam
ER  -