TY  - JOUR
A1  - Tsilimigras, Diamantis I.
A1  - Bibli, Sofia Iris
A1  - Siasos, Gerasimos
A1  - Oikonomou, Evangelos
A1  - Perrea, Despina N.
A1  - Filis, Konstantinos
A1  - Tousoulis, Dimitrios
A1  - Sigala, Fragiska
T1  - Regulation of long non-coding RNAs by statins in atherosclerosis
T2  - Biomolecules
N2  - Despite increased public health awareness, atherosclerosis remains a leading cause of mortality worldwide. Significant variations in response to statin treatment have been noted among different populations suggesting that the efficacy of statins may be altered by both genetic and environmental factors. The existing literature suggests that certain long noncoding RNAs (lncRNAs) might be up- or downregulated among patients with atherosclerosis. LncRNA may act on multiple levels (cholesterol homeostasis, vascular inflammation, and plaque destabilization) and exert atheroprotective or atherogenic effects. To date, only a few studies have investigated the interplay between statins and lncRNAs known to be implicated in atherosclerosis. The current review characterizes the role of lncRNAs in atherosclerosis and summarizes the available evidence related to the effect of statins in regulating lncRNAs.
KW  - statin
KW  - RNA
KW  - epigenetics
KW  - vascular biology
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62128
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621287
SN  - 2218-273X
N1  - This research work was supported by the Onassis Foundation—Scholarship ID: G ZO 030-1/2018-2019.
VL  - 11
IS  - 5, art. 623
SP  - 1
EP  - 14
PB  - MDPI
CY  - Basel
ER  -